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Human Integrative Immunology
- Fernando A. Arosa, Ph.D.
The way scientists envision Immunology is changing and a comprehensive dissection of the mechanisms that control the life span and differentiation of T cells is essential to understand their function in health and disease. Our research activities aim at:
- Elucidating the molecular mechanisms regulating cell growth, survival and differentiation of human CD8+ T cells by environmental signals, such as those provided by the g-common cytokine IL-15 and novel erythrocyte derived growth and survival factors, and how they impact on the expression of Killer Immunoglobulin-like Receptors (KIR).
- Understanding why cell surface MHC class I molecules have a tendency to become free-heavy chains and form homotypic/heterotypic associations as well as elucidating the role of these "new" cell surface structures in the regulation of cell-cell communication and function, for instance through interactions with KIR.
|Fernando A. Arosa||Assistant email@example.com|
|Elsa M. Cardoso||Assistant Professorfirstname.lastname@example.org|
|Ana Sofia Botelho||Adjunct email@example.com|
|Isabel Baldaia||Marter student|
Relevant Publications (selected from a total of 30)
1. Antunes RF, Brandão C, Maia M, Arosa FA (2010). Human red blood cells secrete a novel cell growth and survival factor for normal and malignant T cells. Immunol. Cell Biol. (in press).
2. Correia MP, Cardoso EM, Pereira CF, Neves R, Uhrberg M, Arosa FA (2009). Hepatocytes and IL-15: a favorable microenvironment for CD8+ T cell survival and differentiation. J. Immunol. 182:6149-59.
3. Antunes RF, Brandão C, Carvalho G, Girão C, Arosa FA (2009). Red blood cells carry out T cell growth and survival bioactivities that are sensitive to cyclosporine A. Cell Mol Life Sci 66:3387-98.
4. Arosa FA, Santos SG, Powis SJ (2007). Open conformers: the hidden face of MHC-I molecules. Trends Immunol 28:115-23.
5. Santos SG, Antoniou A, Powis SJ, Arosa FA (2006). Lack of tyrosine 320 impairs spontaneous endocytosis and enhances release of HLA-B27 molecules. J. Immunol. 176:2942-9.
6. Stewart CA, Laugier-Anfossi F, Vely F,Saulquin X, Riedmuller J, Tisserant A, Gauthier L, Romagné F, Ferracci G, Arosa FA, Moretta A, Sun PD, Ugolini S, Vivier E (2005). Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc. Natl. Acad. Sci. USA. 102:13224-9.
7. Santos SG, Powis SJ, Arosa FA (2004). Misfolding of MHC-class I molecules in activated T cells allows cis-interactions with receptors and signaling molecules and is associated with tyrosine phosphorylation. J. Biol. Chem. 279:53062-70.
8. Alves NM, Hooibrink B, Arosa FA, van Lier RAW (2003). IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. Blood 102:2541-6.
9. Fonseca AM, Porto G, Uchida K, Arosa FA. (2001). Red blood cells inhibit activation induced cell death and oxidative stress in human peripheral blood T lymphocytes. Blood 97:3152-60.
10. Arosa FA, de Jesus O, Porto G, Carmo AM, de Sousa M. (1999). Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. J. Biol. Chem. 274:16917-22.
Project Title: Immunomodulatory properties of transfusional blood units
Funding entity: CESPU, CRL
Project identification: 03‐GBMC‐CICS‐10
Period covered: from 01-01-2010 to 31-12-2011
PI: Fernando A. Arosa
Project Title: Cytokine profile of IL-15-diferentiated human CD8+ T cells
Funding entity: CESPU, CRL
Project identification: 02‐GBMC‐CICS‐09
Period covered: from 01-01-2009 to 31-12-2010
PI: Elsa M. Cardoso